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Plagiarists at ZS Genetics Confirmed and Use My Sequencing Inventions20-01-2014, 21:51. Разместил: admin |
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Plagiarists at ZS Genetics Confirmed and Use My Sequencing Inventions Alexander Cherkasky alexcherkasky@googlemail.com http://feasibilityofalexandercherkaskysinven.blogspot.de/ ZS Genetics’ claimed technology comprises long-read, single molecule DNA sequencing technology, with extremely long read-length and single-molecule sampling, as well as labeling DNA and sequencing by electron microscopy. DNA sequence is prepared and linearized/stretched. The substrate is preferably transparent. My prior patent publications disclose: 1. Sequencing by microscopy, especially electron microscopy (using an electron microscope) or other physico-optical methods (DE19937512 A1 (filed on August 09, 1999 and published on February 15, 2001), (see Abstract; column 1, line 68; column 3, line 55 and claim 2), DE19937512 B4 (0009, 0018 and claim 1), DE19929530 A1 (filed on June 28, 1999 and published on January 04, 2001), (Abstract; column 1, line 64; column 2, line 54; column 3, line 68; column 4, line 4 and claim 16), DE19929530 B4 (0006, 0013 and 0024)), 2. Sample preparation including degradation of chromosomes, preparation and fixing of DNA sequence (long, very long or extremely long single molecule DNA sequence(s)) to the (long) substrate, (with or without DNA modification), DNA stretching (and immobilization) on the substrate, (extremely long read-length and single-molecule sampling) for the sequencing by Electron Microscopy (DE19937512 A1 (Abstract, columns 1-7, claims 1, 3-9, 13-15), DE19937512 B4 (0009-0017, 0020-0046 (including lay down DNA sequence from pipette) as well as claim 1), DE19929530 A1 (columns 2-9), DE19929530 B4 (0007-0022, 0026-0067)), 3. Transparent substrates (DE19937512 A1 (column 2, lines 49-50, as well as claim 10), DE19937512 B4 (0013), DE19929530 A1 (column 4, lines 6-9), DE19929530 B4 (0025)), 4. Conversion of (long) double-stranded DNA sequences to single-stranded DNA sequences, for example by using enzymes (DE19937512 A1 (column 3, lines 62-68; column 7, lines 1-11; claims 9, 14, 15), DE19937512 B4 (0019, 0043), DE19929530 A1 (claim 26)), 5. Labeling (all labels of nucleic acids, especially DNA, every label of nucleic acids, especially DNA, and each labeled nucleic acid, especially DNA, including iodine and bromine labels/labeling, are covered by my published patent application DE102007027596 A1 (filed on June 12, 2007, published on January 29, 2009; claims 6, 8, as well as 1 and 4 (use as filter and absorption substances))), and 6. Reading the sequence of long segments of DNA, long-reads of DNA molecules (individual or single DNA molecules) and automatic and multiparallel sequencing (DE19937512 A1, (column 3, lines 52-62; column 6, line 68; column 7, line 1; claims 16, 17 and 18), DE19937512 B4 (0009, 0018, 0019, 0032 and 0036), DE19929530 A1 (column 8, lines 27-51)). Thus, it is possible, that through reexaminations with the USPTO the patents (issued by error of examiners) of ZS Genetics can be invalidated and patent applications of ZS Genetics can be rejected, because they are not new and not inventive. In that possible case, ZS Genetics will not be protected from competitors. Thus, investors will reduce their expectations, especially because the perspectives of revenues will be reduced and everybody will be able to use the results/fruits of the experimental work of ZS Genetics. ZS Genetics does not disclose this information, especially to investors. The October 2012 article in Microscopy and Microanalysis (the October edition of Microscopy and Microanalysis (October 10, 2012)) of scientists at Harvard University (team led by Professor David Bell, at the School of Engineering and Applied Sciences and the Center for Nanoscale Systems at Harvard University), the University of New Hampshire (Professor Kelly Thomas, Chair of the Hubbard Center for Genome Studies at the University of New Hampshire) and ZS Genetics (William Glover, President of ZS Genetics) confirmed feasibility of my sequencing inventions. See also http://feasibilityofalexandercherkaskysinven.blogspot.de/ for more information. Вернуться назад |